Alternative Splicing
Alternative splicing is a process in which a single pre-mRNA can be spliced in different ways to produce multiple mRNA isoforms. This process is regulated by various factors such as splicing enhancers and silencers, spliceosome machinery, and RNA-binding proteins. Alternative splicing plays a crucial role in increasing the diversity of gene expression and protein function, and it is estimated that up to 95% of human multi-exon genes undergo alternative splicing. This process is also implicated in various diseases such as cancer, neurodegenerative disorders, and genetic disorders. Studying alternative splicing patterns can provide insights into disease mechanisms and potential therapeutic targets.
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